Drug Details
| General Information of the Drug (ID: DR5410) | ||||
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| Name |
Recombinant mutant human TRAIL
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| Disease | Colorectal cancer [ICD-11: 2B91] | Investigative | [1] | |
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| Arsenic trioxide | Realgar and orpiment | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Molecule(s)
Regulation |
Up-regulation | Expression | ADAR | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | AIFM1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CAPNS1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CBX3 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | HNRNPK | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | ILF3 | Molecule Info | |||
| Up-regulation | Expression | PCBP1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | STAT1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | THRAP3 | Molecule Info | |||
| In-vitro Model | RPMI-8226 | CVCL_0014 | Plasma cell myeloma | Homo sapiens | ||
| U266B1 | CVCL_0566 | Plasma cell myeloma | Homo sapiens | |||
| Experimental
Result(s) |
ATO and rmhTRAIL had synergistic or additive effects on proliferation inhibition and apoptosis induction in MM cells, and the mechanism underlying the two-drug combination might involve regulation of the expression of several proteins affected by ATO and rmhTRAIL. | |||||
| Target and Pathway | ||||
|---|---|---|---|---|
| Target(s) | Herpes simplex virus Thymidine kinase (HSV TK) | Molecule Info | [3] | |
