Drug Details
| General Information of the Drug (ID: DR6085) | ||||
|---|---|---|---|---|
| Name |
NL-101
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| Disease | Anaplastic large cell lymphoma [ICD-11: 2A90] | Investigative | [1] | |
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| Daunorubicin | Streptomyces peucetius | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Molecule(s)
Regulation |
Up-regulation | Expression | BAD | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | BCL2L11 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP7 | Molecule Info |
Pathway MAP
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| In-vitro Model | MV4-11 | CVCL_0064 | Childhood acute monocytic leukemia | Homo sapiens | ||
| MOLM-13 | CVCL_2119 | Adult acute myeloid leukemia | Homo sapiens | |||
| THP-1 | CVCL_0006 | Childhood acute monocytic leukemia | Homo sapiens | |||
| HL-60 | CVCL_0002 | Adult acute myeloid leukemia | Homo sapiens | |||
| Kasumi-1 | CVCL_0589 | Acute myeloid leukemia | Homo sapiens | |||
| NOMO-1 | CVCL_1609 | Adult acute monocytic leukemia | Homo sapiens | |||
| OCI-AML-2 | CVCL_1619 | Adult acute myeloid leukemia | Homo sapiens | |||
| OCI-AML-3 | CVCL_1844 | Adult acute myeloid leukemia | Homo sapiens | |||
| Experimental
Result(s) |
NL 101 in combination with daunorubicin could be an alternative novel therapeutic strategy for treating leukemia. | |||||
| Target and Pathway | ||||
|---|---|---|---|---|
| Target(s) | TNF-related apoptosis-inducing ligand (TRAIL) | Molecule Info | [3] | |
| KEGG Pathway | Cytokine-cytokine receptor interaction | Click to Show/Hide | ||
| 2 | FoxO signaling pathway | |||
| 3 | Apoptosis | |||
| 4 | Natural killer cell mediated cytotoxicity | |||
| 5 | Measles | |||
| 6 | Influenza A | |||
| NetPath Pathway | IL2 Signaling Pathway | Click to Show/Hide | ||
| 2 | IL4 Signaling Pathway | |||
| 3 | TGF_beta_Receptor Signaling Pathway | |||
| 4 | TNFalpha Signaling Pathway | |||
| 5 | Leptin Signaling Pathway | |||
| Panther Pathway | Apoptosis signaling pathway | Click to Show/Hide | ||
| Pathway Interaction Database | TRAIL signaling pathway | Click to Show/Hide | ||
| 2 | Caspase Cascade in Apoptosis | |||
| Reactome | Ligand-dependent caspase activation | Click to Show/Hide | ||
| 2 | Regulation by c-FLIP | |||
| 3 | RIPK1-mediated regulated necrosis | |||
| 4 | CASP8 activity is inhibited | |||
| 5 | Dimerization of procaspase-8 | |||
| 6 | TRAIL signaling | |||
| WikiPathways | Apoptosis | Click to Show/Hide | ||
| 2 | Extrinsic Pathway for Apoptosis | |||
| 3 | Apoptosis Modulation and Signaling | |||
| 4 | TP53 Network | |||
