Drug Details

General Information of the Drug (ID: DR7470)
Name
Combretastatin A-4 phosphate
Synonyms
Fosbretabulin; Combretastatin A-4 phosphate; (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenyl dihydrogen phosphate; 222030-63-9; Fosbretabulin disodium; UNII-I5590ES2QZ; Fosbretabulin free acid; combretastatin A4 phosphate; CA4DP; I5590ES2QZ; CA 4DP; 222030-63-9 (free acid); Phenol, 2-methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-, dihydrogen phosphate; Fosbretabulin [INN]; Phosbretabulin; [2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] dihydrogen phosphate; SCHEMBL66079; GTPL8857; CHEMBL1206232; ZINC1543513; 2-Methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)phenyl phosphate; DB12577; Z-3247; Q5150956
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Molecular Type
Small molecule
Disease Rheumatoid arthritis [ICD-11: FA20] Phase 2 [1]
Structure
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2D MOL

3D MOL

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Formula
C18H21O8P
PubChem CID
5351387
Canonical SMILES
COC1=C(C=C(C=C1)C=CC2=CC(=C(C(=C2)OC)OC)OC)OP(=O)(O)O
InChI
1S/C18H21O8P/c1-22-14-8-7-12(9-15(14)26-27(19,20)21)5-6-13-10-16(23-2)18(25-4)17(11-13)24-3/h5-11H,1-4H3,(H2,19,20,21)/b6-5-
InChIKey
WDOGQTQEKVLZIJ-WAYWQWQTSA-N
CAS Number
CAS 222030-63-9
TTD Drug ID
D07JVO
DrugBank ID
DB12577
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Vincristine      Catharanthus roseus     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Up-regulation Expression IL19  Molecule Info 
Pathway MAP
Up-regulation Expression TNF  Molecule Info 
Pathway MAP
Down-regulation Expression TRIM26  Molecule Info 
Pathway MAP
                    In-vitro Model Hep-G2 CVCL_0027 Hepatocellular carcinoma Homo sapiens
                    In-vivo Model Rats received single I.P injection of Diethylnitrosamine (DENA) 200 mg/kg body weight, freshly dissolved in sterile 0.9% saline, as an inducer for hepatocellular carcinoma.
                    Experimental
                    Result(s)		 CA4-P showed a potential anti-cancer activity against hepatocellular carcinoma and this effect was greatly enhanced by co-administration with vincristine.
References
Reference 1 ClinicalTrials.gov (NCT02279602) Rollover Protocol for Subjects Who Have Responded on Study 4218s - A Phase 2 Study. U.S. National Institutes of Health.
Reference 2 Enhanced anticancer effect of Combretastatin A-4 phosphate when combined with vincristine in the treatment of hepatocellular carcinoma. Biomed Pharmacother. 2017 May;89:36-46.
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