Drug Details

General Information of the Drug (ID: DR8145)
Name
N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine
Disease Lung cancer [ICD-11: 2C25] Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Myo-inositol      Fragaria x ananassa     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model The animal models were established in mice by a mixture of B[a]P plus NNK.
                    Experimental
                    Result(s)		 PEITC-NAC plus MI was significantly more effective than the agents alone.
References
Reference 1 Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination. Carcinogenesis. 2010 Sep;31(9):1634-41.
Reference 2 Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and myo-inositol, individually and in combination. Carcinogenesis. 2002 Sep;23(9):1455-61.
 Download Picture         KEGG Link