Drug Details

General Information of the Drug (ID: DR9147)
Name
DC/Dribble vaccine
Molecular Type
Vaccine
Disease Lung cancer [ICD-11: 2C25] Phase 1 [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Elemene      Pogostemon cablin     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Up-regulation Expression IFNG  Molecule Info 
Pathway MAP
                    In-vitro Model BNL1MEA.7R.1 Hepatocellular carcinoma Rattus norvegicus
                    Experimental
                    Result(s)		 Beta-elemene combined DC/Dribble vaccine could induce specific immune cells to secrete secretory cells, thus exerting its anti-tumor effect.
References
Reference 1 ClinicalTrials.gov (NCT03057340) The Treatment of Advanced Lung Cancer With Dribbles Antigen by Targeting Activation of Tcells
Reference 2 [Treatment of hepatic cancer in mice by beta-elemene combined DC/Dribble vaccine: an immune mechanism research]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Feb;33(2):214-9.
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