Drug Details
| General Information of the Drug (ID: DR9274) | ||||
|---|---|---|---|---|
| Name |
6-OH-11-O-Hydroxyphenanthrene
|
|||
| Molecular Type |
Small molecule
|
|||
| Disease | Breast cancer [ICD-11: 2C60] | Investigative | [1] | |
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| Epigallocatechin gallate | Hamamelis virginiana | Click to Show/Hide the Molecular Data of This NP | ||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
|
|||||
| Molecule(s)
Regulation |
Down-regulation | Expression | COX-2 | Molecule Info |
Pathway MAP
|
|
| Down-regulation | Expression | MMP-2 | Molecule Info |
Pathway MAP
|
||
| Down-regulation | Expression | MMP-9 | Molecule Info |
Pathway MAP
|
||
| Down-regulation | Expression | MYCN | Molecule Info |
Pathway MAP
|
||
| In-vitro Model | SK-N-BE(2)-C | CVCL_0529 | Neuroblastoma | Homo sapiens | ||
| Experimental
Result(s) |
Epigallocatechin-3-gallate and 6-OH-11-O-hydroxyphenanthrene limit BE(2)-C neuroblastoma cell growth and neurosphere formation in vitro. | |||||
| Target and Pathway | ||||
|---|---|---|---|---|
| Target(s) | Angiotensin II receptor type-1 (AGTR1) | Molecule Info | [3] | |
| KEGG Pathway | Calcium signaling pathway | Click to Show/Hide | ||
| 2 | cGMP-PKG signaling pathway | |||
| 3 | Neuroactive ligand-receptor interaction | |||
| 4 | Adrenergic signaling in cardiomyocytes | |||
| 5 | Vascular smooth muscle contraction | |||
| 6 | Renin-angiotensin system | |||
| 7 | Renin secretion | |||
| 8 | Pathways in cancer | |||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | Click to Show/Hide | ||
| Panther Pathway | Angiotensin II-stimulated signaling through G proteins and beta-arrestin | Click to Show/Hide | ||
| Pathwhiz Pathway | Angiotensin Metabolism | Click to Show/Hide | ||
| 2 | Muscle/Heart Contraction | |||
| Pathway Interaction Database | Arf6 trafficking events | Click to Show/Hide | ||
| 2 | Arf6 signaling events | |||
| 3 | Angiopoietin receptor Tie2-mediated signaling | |||
| Reactome | Peptide ligand-binding receptors | Click to Show/Hide | ||
| 2 | G alpha (q) signalling events | |||
| WikiPathways | ACE Inhibitor Pathway | Click to Show/Hide | ||
| 2 | GPCRs, Class A Rhodopsin-like | |||
| 3 | Gastrin-CREB signalling pathway via PKC and MAPK | |||
| 4 | Peptide GPCRs | |||
| 5 | Allograft Rejection | |||
| 6 | GPCR ligand binding | |||
| 7 | GPCR downstream signaling | |||
