Drug Combination Details
| General Information of the Combination (ID: C21366) | |||||
|---|---|---|---|---|---|
| Name | Epigallocatechin gallate NP Info | + | 6-OH-11-O-Hydroxyphenanthrene Drug Info | ||
| Structure |
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+ |
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| Disease |
Adrenocortical carcinoma
[ICD-11: 2D11]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | COX-2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MMP-2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MMP-9 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MYCN | Molecule Info |
Pathway MAP
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| In-vitro Model | SK-N-BE(2)-C | CVCL_0529 | Neuroblastoma | Homo sapiens | ||
| Experimental
Result(s) |
Epigallocatechin-3-gallate and 6-OH-11-O-hydroxyphenanthrene limit BE(2)-C neuroblastoma cell growth and neurosphere formation in vitro. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Epigallocatechin-3-gallate and 6-OH-11-O-Hydroxyphenanthrene Limit BE(2)-C Neuroblastoma Cell Growth and Neurosphere Formation In Vitro. Nutrients. 2018 Aug 22;10(9):1141. | |||
