Drug Details

General Information of the Drug (ID: DR9842)
Name
Chloramphenicol
Disease Bacterial infection [ICD-11: 1A00-1C4Z] Approved [1]
TTD Drug ID
D0X6IU
DrugBank ID
DB00446
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Amentoflavone      Gingko biloba     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vitro Model Enterococcus faecium ATCC 19434 Microorganism model Enterococcus faecium
Staphylococcus aureus ATCC 25923 Microorganism model Staphylococcus aureus
Streptococcus mutans ATCC 3065 Microorganism model Streptococcus mutans
Escherichia coli ATCC 43895 Microorganism model Escherichia coli
Escherichia coli ATCC 25922 Microorganism model Escherichia coli
Pseudomonas aeruginosa ATCC 27853 Microorganism model Pseudomonas aeruginosa
                    Experimental
                    Result(s)		 Amentoflavone had a considerable antibacterial effect and synergistic interaction with antibiotics against various bacterial strains. The formation of hydroxyl radical would be a cause of the synergistic effect and that this oxidative stress originated from a transient NADH depletion. .
Target and Pathway
Target(s) Bacterial 23S ribosomal RNA (Bact 23S rRNA)  Molecule Info  [3]
References
Reference 1 Has nature already identified all useful antibacterial targets Curr Opin Microbiol. 2008 Oct;11(5):387-92.
Reference 2 Antibacterial effect of amentoflavone and its synergistic effect with antibiotics. J Microbiol Biotechnol. 2013;23(7):953-8.
Reference 3 Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin. Mol Microbiol. 2004 Dec;54(5):1287-94.
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