Natural Product (NP) Details

General Information of the NP (ID: NP0310)
Name
Succinic acids
Species Origin Pinus ...     Click to Show/Hide
Pinus
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Pinopsida
Family: Pinaceae
Genus: Pinus
Disease Uterine cancer [ICD-11: 2C76] Investigative [1]
Herb ID
HBIN045062
SymMap ID
SMIT00031
TCMSP ID
MOL000346
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Trimetazidine      Angina pectoris     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model The study was carried out on 40 male Wistar rats (230-250 g).
                    Experimental
                    Result(s)		 A mixture of mitochondrial substrates of succinic and malic acids more effectively than antihypoxant trimetazidine prevented functional and metabolic disorders in rat myocardium during acute ischemia.
References
Reference 1 A new target for the treatment of endometrium cancer by succinic acid. Cell Mol Biol (Noisy-le-grand). 2018 Jan 31;64(1):60-63.
Reference 2 Cardioprotective effects of trimetazidine and a combination of succinic and malic acids in acute myocardial ischemia. Bull Exp Biol Med. 2008 Aug;146(2):218-22.
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