Drug Combination Details
| General Information of the Combination (ID: C95038) | |||||
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| Name | Malic acids + Succinic acids | + | Trimetazidine | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Malic acids NP Info | Drug Info | |||
| Structure |
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| Name | Succinic acids NP Info | ||||
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| Disease |
Coronary heart disease
[ICD-11: BA80]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | The study was carried out on 40 male Wistar rats (230-250 g). | |||||
| Experimental
Result(s) |
A mixture of mitochondrial substrates of succinic and malic acids more effectively than antihypoxant trimetazidine prevented functional and metabolic disorders in rat myocardium during acute ischemia. | |||||
| References | ||||
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| Reference 1 | Cardioprotective effects of trimetazidine and a combination of succinic and malic acids in acute myocardial ischemia. Bull Exp Biol Med. 2008 Aug;146(2):218-22. | |||
