Natural Product (NP) Details
| General Information of the NP (ID: NP4822) | |||||
|---|---|---|---|---|---|
| Name |
Malic acids
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| Species Origin | Actinidia chinensis ... | Click to Show/Hide | |||
| Actinidia chinensis | |||||
| Disease | Hypertension [ICD-11: BA00] | Phase 3 | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
| Trimetazidine | Angina pectoris | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
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| In-vivo Model | The study was carried out on 40 male Wistar rats (230-250 g). | |||||
| Experimental
Result(s) |
A mixture of mitochondrial substrates of succinic and malic acids more effectively than antihypoxant trimetazidine prevented functional and metabolic disorders in rat myocardium during acute ischemia. | |||||
