Natural Product (NP) Details
| General Information of the NP (ID: NP2632) | |||||
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| Name |
Fucoidan
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| Synonyms |
ZINC97974745
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| Species Origin | Undaria pinnatifida ... | Click to Show/Hide | |||
| Undaria pinnatifida | |||||
| Disease | Head and neck cancer [ICD-11: 2D42] | Phase 2 | [1] | ||
| Structure |
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| Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product | |||||
| Formula |
C7H14O7S
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| PubChem CID | |||||
| Canonical SMILES |
CC1C(C(C(C(O1)C)OS(=O)(=O)O)O)O
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| InChI |
1S/C7H14O7S/c1-3-5(8)6(9)7(4(2)13-3)14-15(10,11)12/h3-9H,1-2H3,(H,10,11,12)/t3-,4+,5-,6+,7-/m1/s1
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| InChIKey |
NLMDZXKCTWKRSQ-IBISWUOJSA-N
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| Herb ID | |||||
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| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
| Gemcitabine | Solid tumour/cancer | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
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| In-vitro Model | SK-UT-1 | CVCL_0533 | Uterine corpus leiomyosarcoma | Homo sapiens | ||
| MES-SA | CVCL_1404 | Uterine corpus sarcoma | Homo sapiens | |||
| Experimental
Result(s) |
Isobolographic analysis demonstrates the additive and synergistic effects of gemcitabine combined with fucoidan in uterine sarcomas and carcinosarcoma cells. | |||||
