Natural Product (NP) Details

General Information of the NP (ID: NP2704)
Name
Dopamine
Synonyms
dopamine; 4-(2-Aminoethyl)benzene-1,2-diol; 3-Hydroxytyramine; 51-61-6; Dopamin; Hydroxytyramin; Oxytyramine; 3,4-dihydroxyphenethylamine; intropin; Dophamine; 2-(3,4-dihydroxyphenyl)ethylamine; 4-(2-Aminoethyl)catechol; hydroxytyramine; Dopaminum; 4-(2-Aminoethyl)pyrocatechol; 4-(2-Aminoethyl)-1,2-benzenediol; 3,4-Dihydroxyphenylethylamine; Dopamina; L-DOPAMINE; ASL 279; Pyrocatechol, 4-(2-aminoethyl)-; 1,2-Benzenediol, 4-(2-aminoethyl)-; Dopaminum [INN-Latin]; Dopamina [INN-Spanish]; 3-Hydroxtyramine; alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane; KW-3-060; Sinemet; 4-(2-aminoethyl)-pyrocatechol; UNII-VTD58H1Z2X; Dynatra; NSC 173182; a-(3,4-Dihydroxyphenyl)-b-aminoethane; 4-(2-Aminoethyl)-1,2-bezenediol; VTD58H1Z2X; CHEBI:18243; NSC-173182; LDP; NCGC00015519-05; Pyrocatechol, 4-(2-aminoethyl)- (8CI); Dopamine [INN:BAN]; DSSTox_CID_2420; 1,2-Benzenediol, 4-(2-aminoethyl)- (9CI); DSSTox_RID_76584; DSSTox_GSID_22420; .alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane; (3H)-Dopamine; Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride; 62-31-7 (HYDROCHLORIDE); CAS-51-61-6; Dopamine (INN); Medopa (TN); NSC169105; HSDB 3068; EINECS 200-110-0; Intropin [*hydrochloride*]; 4-(2-Aminoethyl)-1,2-benzenediol hydrochloride; SR-01000075366; .beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride; m-Hydroxytyramine-; Dopamine (USAN)(*hydrochloride*); IP 498; Intropin (Salt/Mix); Spectrum_001012; 1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium; CHEMBL59; Spectrum2_001023; Spectrum3_000406; Spectrum4_000525; Spectrum5_000945; Lopac-H-8502; Biomol-NT_000001; bmse000909; bmse000933; SCHEMBL8505; 1, 4-(2-aminoethyl)-; Lopac0_000586; Oprea1_088821; BSPBio_001932; GTPL940; KBioGR_001129; KBioGR_002388; KBioGR_002484; KBioSS_001492; KBioSS_002393; KBioSS_002491; cid_65340; BIDD:ER0506; DivK1c_000780; SPECTRUM1505155; SPBio_001205; BPBio1_001123; 153C5321-5FEE-4B0B-8925-F388F0EEEBD1; DTXSID6022420; BDBM55121; KBio1_000780; KBio2_001492; KBio2_002388; KBio2_002484; KBio2_004060; KBio2_004956; KBio2_005052; KBio2_006628; KBio2_007524; KBio2_007620; KBio3_001152; KBio3_002867; KBio3_002962; ZINC33882; cMAP_000036; cMAP_000065; NINDS_000780; DOPAMINE, [7-3H(N)]; HMS3743I03; AMY40803; BCP34189; Tox21_110167; 2-(3, 4-Dihydroxyphenyl)ethylamine; 2-(3,4-dihydroxyphenyl) ethylamine; ANW-54385; BBL013043; MFCD00130258; NSC173182; SBB004044; STK301601; 3,4-DihydroxyphenylA currencythylamin; AKOS003790978; Tox21_110167_1; CCG-204675; DB00988; FS-5341; MCULE-7558764100; SDCCGSBI-0050568.P005; 2-(3,4-Dihydroxyphenyl)-1-ethanamine; 4-(2-Amino-ethyl)-benzene-1,2-diol; 4-(2-Aminoethyl)-1,2-benzenediol #; IDI1_000780; UPCMLD0ENAT5885989:001; NCGC00015519-01; NCGC00015519-02; NCGC00015519-03; NCGC00015519-04; NCGC00015519-07; NCGC00015519-08; NCGC00015519-09; NCGC00015519-10; NCGC00015519-11; NCGC00015519-25; NCGC00096050-01; NCGC00096050-02; NCGC00096050-03; NCGC00096050-04; NCGC00096050-05; 50444-17-2; AK100905; BP-23276; ST048774; 4-(2-aminoethyl)pyrocatechol;hydrochloride; SBI-0050568.P004; FT-0698513; T7923; 2-(4-Hydroxy-5-oxylatophenyl)-1-ethanaminium; C03758; D07870; 13510-EP2269989A1; 13510-EP2270011A1; 13510-EP2272537A2; 13510-EP2272825A2; 13510-EP2272847A1; 13510-EP2275420A1; 13510-EP2277882A1; 13510-EP2280010A2; 13510-EP2281559A1; 13510-EP2281815A1; 13510-EP2281819A1; 13510-EP2284169A1; 13510-EP2284170A1; 13510-EP2284171A1; 13510-EP2286811A1; 13510-EP2287161A1; 13510-EP2287162A1; 13510-EP2287165A2; 13510-EP2287166A2; 13510-EP2292620A2; 13510-EP2295437A1; 13510-EP2295439A1; 13510-EP2298312A1; 13510-EP2298313A1; 13510-EP2298731A1; 13510-EP2298734A2; 13510-EP2298758A1; 13510-EP2298759A1; 13510-EP2298775A1; 13510-EP2298776A1; 13510-EP2301540A1; 13510-EP2301933A1; 13510-EP2305260A1; 13510-EP2305633A1; 13510-EP2305640A2; 13510-EP2305644A1; 13510-EP2305648A1; 13510-EP2305650A1; 13510-EP2305652A2; 13510-EP2305656A1; 13510-EP2305659A1; 13510-EP2305664A1; 13510-EP2305675A1; 13510-EP2305689A1; 13510-EP2308828A2; 13510-EP2308867A2; 13510-EP2308870A2; 13510-EP2308875A1; 13510-EP2311494A1; 13510-EP2311801A1; 13510-EP2311802A1; 13510-EP2311803A1; 13510-EP2311818A1; 13510-EP2311827A1; 13510-EP2311828A1; 13510-EP2311835A1; 13510-EP2314571A2; 13510-EP2316470A2; 13510-EP2316836A1; 13510-EP2371814A1; 4-(2-azanylethyl)benzene-1,2-diol;hydrochloride; AB00053463-12; AB00053463_13; AB00053463_14; L000232; Q170304; SR-01000075366-7; Oseltamivir-d3;Hydroxytyramin;4-(2-Aminoethyl)benzene-1,2-diol; 70097-41-5
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Species Origin Lactiplantibacillus plantarum ...     Click to Show/Hide
Lactiplantibacillus plantarum
SuperKingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactiplantibacillus
Species: Lactiplantibacillus plantarum
Disease Parkinson's disease [ICD-11: 8A00] Approved [1]
Structure
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2D MOL

3D MOL

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Formula
C8H11NO2
PubChem CID
681
Canonical SMILES
C1=CC(=C(C=C1CCN)O)O
InChI
1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
InChIKey
VYFYYTLLBUKUHU-UHFFFAOYSA-N
CAS Number
CAS 51-61-6
ChEBI ID
CHEBI:18243
Herb ID
HBIN024421
SymMap ID
SMIT01386
TTD Drug ID
D0T7OW
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Lidocaine      Corneal disease     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Male adult Sprague-Dawley rats, weighing 201 to 251 g were used in this study.
                    Experimental
                    Result(s)		 Serotonin and dopamine produce dose-related cutaneous analgesic effects as an infiltrative anesthetic.
Target and Pathway
Target(s) Dopamine D2 receptor (D2R)  Molecule Info  [3]
KEGG Pathway Rap1 signaling pathway Click to Show/Hide
2 cAMP signaling pathway
3 Neuroactive ligand-receptor interaction
4 Gap junction
5 Dopaminergic synapse
6 Parkinson's disease
7 Cocaine addiction
8 Alcoholism
Panther Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway Click to Show/Hide
2 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
3 Dopamine receptor mediated signaling pathway
4 Nicotine pharmacodynamics pathway
Reactome Dopamine receptors Click to Show/Hide
2 G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction Click to Show/Hide
2 Monoamine GPCRs
3 GPCRs, Class A Rhodopsin-like
4 Genes and (Common) Pathways Underlying Drug Addiction
5 GPCR ligand binding
6 GPCR downstream signaling
7 Nicotine Activity on Dopaminergic Neurons
References
Reference 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 940).
Reference 2 Synergistic Effects of Serotonin or Dopamine Combined With Lidocaine at Producing Nociceptive Block in Rats. Reg Anesth Pain Med. May/Jun 2017;42(3):351-356.
Reference 3 The Detection of Dopamine Gene Receptors (DRD1-DRD5) Expression on Human Peripheral Blood Lymphocytes by Real Time PCR. Iran J Allergy Asthma Immunol. 2004 Dec;3(4):169-74.
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