Drug Combination Details
| General Information of the Combination (ID: C43330) | |||||
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| Name | Serotonin + Dopamine | + | Lidocaine | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Serotonin NP Info | Drug Info | |||
| Structure |
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| Name | Dopamine NP Info | ||||
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| Disease |
Pain
[ICD-11: MG30-MG3Z]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | Male adult Sprague-Dawley rats, weighing 201 to 251 g were used in this study. | |||||
| Experimental
Result(s) |
Serotonin and dopamine produce dose-related cutaneous analgesic effects as an infiltrative anesthetic. | |||||
| References | ||||
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| Reference 1 | Synergistic Effects of Serotonin or Dopamine Combined With Lidocaine at Producing Nociceptive Block in Rats. Reg Anesth Pain Med. May/Jun 2017;42(3):351-356. | |||
