Natural Product (NP) Details

General Information of the NP (ID: NP7092)
Name
Green tea catechins
Species Origin Theaceae ...     Click to Show/Hide
Theaceae
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Ericales
Family: Theaceae
Disease Lung cancer [ICD-11: 2C25] Phase 2 [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Sucralfate      Acne vulgaris     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Male NGS/Sea Mongolian gerbils (17 weeks old) were infected with H. pylori (ATCC43504).
                    Experimental
                    Result(s)		 The CFU of Helicobacter pylori was significantly decreased by GTC-scf.
          Methotrexate      Leukaemia     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [3]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vitro Model Pseudomonas aeruginosa Microorganism model Pseudomonas aeruginosa
Staphylococcus aureus Microorganism model Staphylococcus aureus
                    Experimental
                    Result(s)		 Green tea extract and catechins potentiated the antimicrobial action of gentamicin against some clinical isolates of S. aureus and standard P. aeruginosa strains.
          Metronidazole + Tetracycline     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [4]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Up-regulation Expression HTRA1  Molecule Info 
Pathway MAP
                    In-vitro Model Porphyromonas gingivalis Microorganism model Porphyromonas gingivalis
                    Experimental
                    Result(s)		 Green tea catechins potentiate the effect of antibiotics and modulate adherence and gene expression in Porphyromonas gingivalis.
References
Reference 1 ClinicalTrials.gov (NCT00611650) Green Tea Extract in Treating Current or Former Smokers With Bronchial Dysplasia
Reference 2 Inhibitory effect of green tea catechins in combination with sucralfate on Helicobacter pylori infection in Mongolian gerbils. J Gastroenterol. 2004 Jan;39(1):61-3.
Reference 3 Effect of Catechins, Green tea Extract and Methylxanthines in Combination with Gentamicin Against Staphylococcus aureus and Pseudomonas aeruginosa: - Combination therapy against resistant bacteria. J Pharmacopuncture. 2016 Dec;19(4):312-318.
Reference 4 Green tea catechins potentiate the effect of antibiotics and modulate adherence and gene expression in Porphyromonas gingivalis. Arch Oral Biol. 2016 May;65:35-43.
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