Natural Product (NP) Details
| General Information of the NP (ID: NP7330) | |||||
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| Name |
Citral
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| Synonyms |
Citral; GERANIAL; 5392-40-5; trans-Citral; (2E)-3,7-dimethylocta-2,6-dienal; geranialdehyde; 3,7-dimethylocta-2,6-dienal; (E)-Citral; Citral a; Geranaldehyde; alpha-Citral; (E)-Geranial; geranal; Genanial; beta-Geranial; 141-27-5; (E)-3,7-Dimethylocta-2,6-dienal; 3,7-Dimethyl-2,6-octadienal; (E)-Neral; 2,6-Octadienal, 3,7-dimethyl-; Lemsyn GB; CITRAL NATURAL; trans-3,7-Dimethyl-2,6-octadienal; 2,6-Octadienal, 3,7-dimethyl-, (2E)-; lemonal; cis-Citral; NCI-C56348; 2,6-Octadienal, 3,7-dimethyl-, (E)-; (E)-3,7-Dimethyl-2,6-octadienal; 3,7-Dimethyl-trans-2,6-octadienal; UNII-758ZMW724E; FEMA No. 2303; 147060-73-9; cis/trans-3,7-Dimethyl-2,6-octadienal; Lemarome n; CHEBI:16980; NSC6170; 758ZMW724E; MFCD00006997; cis-3,7-Dimethyl-2,6-octadienal; NSC 6170; Citral alpha; Citral, analytical standard; Citral (natural); Z-Citral; Citral, mixture of cis and trans; Caswell No. 221B; citral-b; FEMA Number 2303; Citral, 95%, mixture of cis and trans; CCRIS 1043; HSDB 993; CITRAL SINTETICO; 2,6-Dimethyloctadien-2,6-al-8; 3,7-Dimethyl-1,2,6-octadienal; EINECS 205-476-5; EINECS 226-394-6; EPA Pesticide Chemical Code 040510; BRN 1721871; BRN 1721873; polyprenal; polyprenals; Natural Citral; AI3-01011; AI3-28519; alpha -Citral; (2Z)-3,7-Dimethyl-2,6-octadienal; Citral N; Citral-A; .alpha.-Citral; 3,6-octadienal; cis/trans Citral;; (2e)-geranial; LEMAROME; 3,2,6-octadienal; (2E)-3,7-Dimethyl-2,6-octadienal; Citral, cis + trans; Citral, 95%; EC 205-476-5; EC 226-394-6; Citral Ex Litsea(Citral ); litsea cubeba oil terpeneless; SCHEMBL23073; 3-01-00-03053 (Beilstein Handbook Reference); 4-01-00-03569 (Beilstein Handbook Reference); GTPL6327; CHEMBL1080997; 3,7- dimethylocta-2,6-dienal; FEMA 2303; DTXSID20881217; CHEBI:137934; WLN: VH1UY1&3Y1&U1; HY-N7083; NSC-6170; ZINC1529208; 3,7-dimethyl-(e)-2,6-octadienal; BBL011666; SBB060834; STK802499; 3,7-dimethyl-(2e)-2,6-octadienal; trans-3,7-dimethyl-octa-2,6-dienal; AKOS000119519; CCG-266236; Citral, natural, >=96%, FCC, FG; CS-W010948; EBD2204555; LMPR0102010003; LS41486; (2E)-3,7-dimethyl-octa-2,6-dienal; Citral, Vetec(TM) reagent grade, 94%; NCGC00091550-01; NCGC00091550-02; NCGC00091550-03; NCGC00091550-04; AS-35309; (2E)-3,7-dimethyl-2,6-octadien-1-al; 2,6- OCTADIENAL, 3,7-DIMETHYL-; S5138; ST50308094; 3,7-DIMETHYL-2,6-OCTADIENAL(TRANS); C01499; C15604; Citral, mixture of cis and trans, >=96%, FG; A829835; Q410888; Q-200867; F0001-1403; UNII-T7EU0O9VPP component WTEVQBCEXWBHNA-JXMROGBWSA-N; 2,6-Octadienal,3,7-dimethyl-, reaction products with Et alc.; GRQ
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| Species Origin | Cymbogogon Citratus ... | Click to Show/Hide | |||
| Cymbogogon Citratus | |||||
| Disease | Breast cancer [ICD-11: 2C60] | Investigative | [1] | ||
| Structure |
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| Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product | |||||
| Formula |
C10H16O
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| PubChem CID | |||||
| Canonical SMILES |
CC(=CCCC(=CC=O)C)C
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| InChI |
1S/C10H16O/c1-9(2)5-4-6-10(3)7-8-11/h5,7-8H,4,6H2,1-3H3/b10-7+
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| InChIKey |
WTEVQBCEXWBHNA-JXMROGBWSA-N
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| CAS Number |
CAS 5392-40-5
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| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
| Pirarubicin | Breast cancer | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
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| Molecule(s)
Regulation |
Down-regulation | Expression | p105 | Molecule Info |
Pathway MAP
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| In-vitro Model | HCT 116 | CVCL_0291 | Colon carcinoma | Homo sapiens | ||
| In-vivo Model | For the colorectal peritoneal carcinomatosis (CRPC) experiments, mouse-derived colorectal cancer cells CT26 (5 * 106 cells in 0.5 mL of serum-free medium) were intraperitoneal inoculated into the flanks of Balb/C mice. | |||||
| Experimental
Result(s) |
Combination treatment of citral potentiates the efficacy of hyperthermic intraperitoneal chemoperfusion with pirarubicin for colorectal cancer. | |||||
| β. A List of Drug(s) Whose Adverse Effect can be Decreased by This NP | ||||||
| Naproxen | Osteoarthritis | Click to Show/Hide the Molecular Data of This Drug | ||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [3] | |||||
| Detail(s) |
Combination Info
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| In-vivo Model | Male Wistar rats aged 7-9 weeks (weight range: 180-220 g) were used in this study. | |||||
| Experimental
Result(s) |
The combination of naproxen and citral reduces nociception and gastric damage in rats. | |||||
| Target and Pathway | ||||
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| Target(s) | Transient receptor cation channel V2 (TRPV2) | Molecule Info | [4] | |
| Transient receptor cation channel V3 (TRPV3) | Molecule Info | [4] | ||
| KEGG Pathway | Inflammatory mediator regulation of TRP channels | Click to Show/Hide | ||
| Reactome | TRP channels | Click to Show/Hide | ||
