Natural Product (NP) Details

General Information of the NP (ID: NP7644)
Name
Tephrosin
Synonyms
Tephrosin; hydroxydeguelin; 76-80-2; deguelinol I; UNII-9C081V83CC; CHEBI:9442; 9C081V83CC; (1R,14R)-14-hydroxy-17,18-dimethoxy-7,7-dimethyl-2,8,21-trioxapentacyclo[12.8.0.03,12.04,9.015,20]docosa-3(12),4(9),5,10,15,17,19-heptaen-13-one; CCRIS 7115; (?)-Tephrosin; (-)-TEPHROSIN; SCHEMBL766277; CHEMBL241806; MEGxp0_001258; DTXSID20878627; HY-N1166; ZINC4098748; BDBM50505206; LMPK12060047; Tephrosin, >=95% (LC/MS-ELSD); MCULE-5773910433; NCGC00347726-02!; CS-0016457; C10535; Q7701343; (7aR,13aR)-13,13a-dihydro-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-3H-bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one; (7aR,13aR)-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one; 3H-Bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one, 13,13a-dihydro-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-, (7aR,13aR)-; 3H-Bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one, 13,13a-dihydro-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-, (7aR-cis)-
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Species Origin Tephrosia vogelii ...     Click to Show/Hide
Tephrosia vogelii
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Fabales
Family: Fabaceae
Genus: Tephrosia
Species: Tephrosia vogelii
Disease Pancreatic cancer [ICD-11: 2C10] Investigative [1]
Structure
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2D MOL

3D MOL

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Formula
C23H22O7
PubChem CID
114909
Canonical SMILES
CC1(C=CC2=C(O1)C=CC3=C2OC4COC5=CC(=C(C=C5C4(C3=O)O)OC)OC)C
InChI
1S/C23H22O7/c1-22(2)8-7-12-15(30-22)6-5-13-20(12)29-19-11-28-16-10-18(27-4)17(26-3)9-14(16)23(19,25)21(13)24/h5-10,19,25H,11H2,1-4H3/t19-,23-/m1/s1
InChIKey
AQBZCCQCDWNNJQ-AUSIDOKSSA-N
CAS Number
CAS 76-80-2
ChEBI ID
CHEBI:9442
Herb ID
HBIN045927
SymMap ID
SMIT13885
TCMSP ID
MOL013198
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          2-deoxy-D-glucose      Solid tumour/cancer     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vitro Model HeLa CVCL_0030 Endocervical adenocarcinoma Homo sapiens
HT-29 CVCL_0320 Colon adenocarcinoma Homo sapiens
SW620 CVCL_0547 Colon adenocarcinoma Homo sapiens
A-549 CVCL_0023 Lung adenocarcinoma Homo sapiens
                    Experimental
                    Result(s)		 The combination of TSN and 2-DG increased the sensitivity of cancer cells to 2-DG.
References
Reference 1 Tephrosin induces apoptosis of human pancreatic cancer cells through the generation of reactive oxygen species. J Cancer. 2021 Jan 1;12(1):270-280.
Reference 2 The combination of tephrosin with 2-deoxy-D-glucose enhances the cytotoxicity via accelerating ATP depletion and blunting autophagy in human cancer cells. Cancer Biol Ther. 2011 Dec 1;12(11):989-96.
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