Natural Product (NP) Details
| General Information of the NP (ID: NP7649) | |||||
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| Name |
Antineoplaston A10
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| Synonyms |
Antineoplaston A10; Antineoplaston A 10; 91531-30-5; UNII-16VY3TM7ZO; N-[(3S)-2,6-dioxopiperidin-3-yl]-2-phenylacetamide; atengenal; 16VY3TM7ZO; ANTINEOPLASTON A-10; A-10; Antineoplaston-A10; A 10; Cengenal; 3-(N-Phenylacetylamino)-2,6-piperidinedione; N-(2,6-Dioxo-3-piperidinyl)benzeneacetamide; 3-((Phenylacetyl)amino)-2,6-piperidinedione; Antineoplaston A10 capsules; ANP-A10; A10; CHEMBL1980825; SCHEMBL20772654; DTXSID00919683; ZINC1590366; MFCD26961095; NSC619130; N-(6-Hydroxy-2-oxo-2,3,4,5-tetrahydropyridin-3-yl)-2-phenylethanimidic acid; DB11702; NSC-619130; SB19788; NCI60_005691; HY-128553; CS-0095862; N-[(3s)-2,6-dioxo-3-piperidyl]-2-phenyl-acetamide; Q27251844; Benzeneacetamide, N-(2,6-dioxo-3-piperidinyl)-, (S)-
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| Species Origin | Homo sapiens ... | Click to Show/Hide | |||
| Homo sapiens | |||||
| Disease | Brain cancer [ICD-11: 2A00] | Phase 2 | [1] | ||
| Structure |
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| Formula |
C13H14N2O3
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| PubChem CID | |||||
| Canonical SMILES |
C1CC(=O)NC(=O)C1NC(=O)CC2=CC=CC=C2
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| InChI |
1S/C13H14N2O3/c16-11-7-6-10(13(18)15-11)14-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H,14,17)(H,15,16,18)/t10-/m0/s1
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| InChIKey |
OQGRFQCUGLKSAV-JTQLQIEISA-N
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| CAS Number |
CAS 91531-30-5
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| Herb ID | |||||
| TTD Drug ID | |||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
| Cis-diamminedichloroplatinum | Ovarian cancer | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
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| In-vitro Model | KIM-1 | CVCL_7969 | Adult hepatocellular carcinoma | Homo sapiens | ||
| In-vivo Model | The KIM-1 cell suspension was implanted subcutaneously in BALB/c athymic mice. | |||||
| Experimental
Result(s) |
The inhibitory effect of the combination of antineoplaston A-10 injection with a small dose of cis-diamminedichloroplatinum on cell and tumor growth of human hepatocellular carcinoma. | |||||
