Natural Product (NP) Details
| General Information of the NP (ID: NP8605) | |||||
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| Name |
6-dehydrogingerdione
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| Synonyms |
6-Dehydrogingerdione; Dehydro-6-gingerdione; CHEMBL555195; SCHEMBL14952275; CHEBI:81311; C17746; 1-(3-Methoxy-4-hydroxyphenyl)-3-hydroxy-1,3-decadiene-5-one; (1E,3Z)-3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)deca-1,3-dien-5-one
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| Species Origin | Zingiber officinale ... | Click to Show/Hide | |||
| Zingiber officinale | |||||
| Disease | Inflammation [ICD-11: N.A.] | Investigative | [1] | ||
| Structure |
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| Formula |
C17H22O4
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| PubChem CID | |||||
| Canonical SMILES |
CCCCCC(=O)C=C(C=CC1=CC(=C(C=C1)O)OC)O
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| InChI |
1S/C17H22O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h7-12,19-20H,3-6H2,1-2H3/b9-7+,15-12-
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| InChIKey |
FZWNRFAUDBWSKY-QNQPVOBRSA-N
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| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
| TNF-related apoptosis inducing ligand | Lung cancer | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
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| Molecule(s)
Regulation |
Up-regulation | Expression | TRAIL-R2 | Molecule Info |
Pathway MAP
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| In-vitro Model | Hep-G2 | CVCL_0027 | Hepatocellular carcinoma | Homo sapiens | ||
| Experimental
Result(s) |
In addition to the mitochondrial- and Fas receptor-mediated apoptotic pathways involved, ROS-dependent and p53-regulated DR5 expression was also demonstrated to play a pivotal role in the synergistic enhancement of TRAIL-induced apoptosis instigated by 6-DG in Hep G2 cells. | |||||
