Molecule Details

Natural Product(s) of This Target
1 Apicidin  NP Info  Investigative Fusarium sp.
Drug(s) of This Target
1 3'-azido-3'-deoxythymidine  Drug Info  Approved Human immunodeficiency virus disease
2 Belinostat  Drug Info  Phase 2 Solid tumour/cancer
3 N-(4-hydroxyphenyl) retinamide  Drug Info  Phase 3 Cervical cancer
4 Trichostatin A  Drug Info  Investigative Solid tumour/cancer
5 Valproic acid  Drug Info  Approved Epilepsy/seizure
References
Reference 1 Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92.
Reference 2 Novel SAHA?bendamustine hybrid NL?101 in combination with daunorubicin synergistically suppresses acute myeloid leukemia. Oncol Rep. 2020 Jul;44(1):273-282.
Reference 3 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
Reference 4 Methylseleninic acid inhibits HDAC activity in diffuse large B-cell lymphoma cell lines. Cancer Chemother Pharmacol. 2011 Sep;68(3):815-21.
Reference 5 Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni. Mol Biochem Parasitol. 2009 Nov;168(1):7-15.
Reference 6 Transcription-independent heritability of induced histone modifications in the mouse preimplantation embryo. PLoS One. 2009 Jun 30;4(6):e6086.