Drug Details
| General Information of the Drug (ID: DR3141) | ||||
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| Name |
N-(4-hydroxyphenyl) retinamide
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| Molecular Type |
Small molecule
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| Disease | Cervical cancer [ICD-11: 2C77] | Phase 3 | [1] | |
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| Epigallocatechin gallate | Hamamelis virginiana | Click to Show/Hide the Molecular Data of This NP | ||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Molecule(s)
Regulation |
Down-regulation | Expression | microRNA 106b | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | microRNA 34a | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | microRNA 7-1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | microRNA 92b | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | microRNA 93 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | microRNA 99a | Molecule Info |
Pathway MAP
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| In-vitro Model | SK-N-BE(2) | CVCL_0528 | Neuroblastoma | Homo sapiens | ||
| IMR-32 | CVCL_0346 | Neuroblastoma | Homo sapiens | |||
| Experimental
Result(s) |
Alterations in expression of specific microRNAs by combination of 4-HPR and EGCG inhibited growth of human malignant neuroblastoma cells. | |||||
| Genistein | Glycine max | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [3] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Molecule(s)
Regulation |
Up-regulation | Expression | AIFM1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CAPN1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | FGF2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | p105 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | VEGFA | Molecule Info |
Pathway MAP
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| In-vitro Model | SK-N-BE(2) | CVCL_0528 | Neuroblastoma | Homo sapiens | ||
| SH-SY5Y | CVCL_0019 | Neuroblastoma | Homo sapiens | |||
| In-vivo Model | Each of neuroblastoma SK-N-BE2 and SH-SY5Y cells (6*106) in 100 ul of 1:1 mixture with Matrigel was implanted by subcutaneous (sc) injection on the flank of each mouse (six weeks-old female athymic nu/nu mice) under isoflurane anesthesia condition. | |||||
| Experimental
Result(s) |
Combination of N-(4-hydroxyphenyl) retinamide and genistein increased apoptosis in neuroblastoma SK-N-BE2 and SH-SY5Y xenografts. | |||||
| Target and Pathway | ||||
|---|---|---|---|---|
| Target(s) | Histone deacetylase (HDAC) | Molecule Info | [4] | |
