Drug Combination Details
| General Information of the Combination (ID: C13798) | |||||
|---|---|---|---|---|---|
| Name | Epigallocatechin gallate NP Info | + | N-(4-hydroxyphenyl) retinamide Drug Info | ||
| Structure |
|
+ |
|
||
| Disease |
Adrenocortical carcinoma
[ICD-11: 2D11]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | microRNA 106b | Molecule Info |
Pathway MAP
|
|
| Up-regulation | Expression | microRNA 34a | Molecule Info |
Pathway MAP
|
||
| Up-regulation | Expression | microRNA 7-1 | Molecule Info |
Pathway MAP
|
||
| Down-regulation | Expression | microRNA 92b | Molecule Info |
Pathway MAP
|
||
| Down-regulation | Expression | microRNA 93 | Molecule Info |
Pathway MAP
|
||
| Up-regulation | Expression | microRNA 99a | Molecule Info |
Pathway MAP
|
||
| In-vitro Model | SK-N-BE(2) | CVCL_0528 | Neuroblastoma | Homo sapiens | ||
| IMR-32 | CVCL_0346 | Neuroblastoma | Homo sapiens | |||
| Experimental
Result(s) |
Alterations in expression of specific microRNAs by combination of 4-HPR and EGCG inhibited growth of human malignant neuroblastoma cells. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Alterations in expression of specific microRNAs by combination of 4-HPR and EGCG inhibited growth of human malignant neuroblastoma cells. Brain Res. 2012 May 15;1454:1-13. | |||
