Drug Combination Details
| General Information of the Combination (ID: C00473) | |||||
|---|---|---|---|---|---|
| Name | Genistein NP Info | + | N-(4-hydroxyphenyl) retinamide Drug Info | ||
| Structure |
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+ |
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| Disease |
Brain cancer
[ICD-11: 2A00]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | AIFM1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CAPN1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | FGF2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | p105 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | VEGFA | Molecule Info |
Pathway MAP
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| In-vitro Model | SK-N-BE(2) | CVCL_0528 | Neuroblastoma | Homo sapiens | ||
| SH-SY5Y | CVCL_0019 | Neuroblastoma | Homo sapiens | |||
| In-vivo Model | Each of neuroblastoma SK-N-BE2 and SH-SY5Y cells (6*106) in 100 ul of 1:1 mixture with Matrigel was implanted by subcutaneous (sc) injection on the flank of each mouse (six weeks-old female athymic nu/nu mice) under isoflurane anesthesia condition. | |||||
| Experimental
Result(s) |
Combination of N-(4-hydroxyphenyl) retinamide and genistein increased apoptosis in neuroblastoma SK-N-BE2 and SH-SY5Y xenografts. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Combination of N-(4-hydroxyphenyl) retinamide and genistein increased apoptosis in neuroblastoma SK-N-BE2 and SH-SY5Y xenografts. Neuroscience. 2009 Sep 29;163(1):286-95. | |||
