Molecule Details
| General Information of the Molecule | ||||
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| Name |
Glucagon-like peptide 1 receptor (GLP1R)
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| Synonyms |
GLP-1R; GLP-1-R; GLP-1 receptor
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| Gene Name |
GLP1R
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| Gene ID | ||||
| Sequence |
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDL
FCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPW RDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIH LNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAAN YYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRN SNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLL GTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERW RLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS Click to Show/Hide
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| Function |
Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. G-protein coupled receptor for glucagon-like peptide 1 (GLP-1).
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| Natural Product(s) of This Target | ||||
|---|---|---|---|---|
| 1 | Morroniside | NP Info | Investigative | Cornus officinalis |
| 2 | Semaglutide | NP Info | Approved | Heloderma suspectum |
| Drug(s) of This Target | ||||
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| 1 | Exenatide | Drug Info | Approved | Type 2 diabetes mellitus |
| 2 | Liraglutide | Drug Info | Approved | Type 2 diabetes mellitus |