Molecule Details
| General Information of the Molecule | ||||
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| Name |
Eukaryotic translation initiation factor 2A (EIF2A)
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| Synonyms |
eIF-2A; 65 kDa eukaryotic translation initiation factor 2A; Basic leucine zipper transcriptional factor ATF-like 2
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| Gene Name |
EIF2A
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| Gene ID | ||||
| Sequence |
MAPSTPLLTVRGSEGLYMVNGPPHFTESTVFPRESGKNCKVCIFSKDGTLFAWGNGEKVN
IISVTNKGLLHSFDLLKAVCLEFSPKNTVLATWQPYTTSKDGTAGIPNLQLYDVKTGTCL KSFIQKKMQNWCPSWSEDETLCARNVNNEVHFFENNNFNTIANKLHLQKINDFVLSPGPQ PYKVAVYVPGSKGAPSFVRLYQYPNFAGPHAALANKSFFKADKVTMLWNKKATAVLVIAS TDVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKAT IFNLKCDPVFDFGTGPRNAAYYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDS TYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSILHKYDVPSNAELWQVSWQPFLDGI FPAKTITYQAVPSEVPNEEPKVATAYRPPALRNKPITNSKLHEEEPPQNMKPQSGNDKPL SKTALKNQRKHEAKKAAKQEARSDKSPDLAPTPAPQSTPRNTVSQSISGDPEIDKKIKNL KKKLKAIEQLKEQAATGKQLEKNQLEKIQKETALLQELEDLELGI Click to Show/Hide
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| Function |
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
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| Uniprot ID | ||||
| Pfam | ||||
| KEGG ID | ||||
| Natural Product(s) of This Target | ||||
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| 1 | 6-shogaol | NP Info | Investigative | Acacia confusa |
| References | ||||
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| Reference 1 | 6-Shogaol induces apoptosis in human leukemia cells through a process involving caspase-mediated cleavage of eIF2Alpha. Mol Cancer. 2013 Nov 12;12(1):135. | |||