Molecule Details
| General Information of the Molecule | ||||
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| Name |
Mycobacterium alanine racemase (MycB alr)
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| Synonyms |
D-alanine racemase; Alr; Alanine racemase; AlaR
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| Gene Name |
MycB alr
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| Sequence |
MQTTEPMTPPAPLASAQTVIDLGAIDHNVRVLRELAGSADVMAVVKADAYGHGALPVART
ALAAGAAALGVATIPEALALREGGITAPVLAWLHPPGTDFAPAIAADVEVAVSSRRQLEQ VTAAAAEVGRTATVTVKVDTGLSRNGVGAADYPEVLDVLRRAQADGAIRVRGLMSHLVHG DDPENPFNGLQGQRLADMRVYAREHGVDYEVAHLCNSPAAMTRPDLAFEMVRPGISLYGL SPIPERGDMGLRPAMTLKCPVALVRSVHAGDGVSYGHRWVADRDTTLGLLPIGYADGVYR ALSGRIDVLIKGRRRRAVGRICMDQFVVDLGPDADDVAVGDDAILFGPGANGEPTAQDWA ELLDTIHYEVVTSPRGRVTRTYLPAGQQD Click to Show/Hide
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| Function |
Catalyzes the interconversion of L-alanine and D- alanine. Overexpression due to a natural mutation in the promoter is responsible for mediating resistance to D-cycloserine (DCS) in mycobacteria.
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| Uniprot ID | ||||
| Pfam | ||||
| TTD ID | ||||
| Natural Product(s) of This Target | ||||
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| 1 | D-cycloserine | NP Info | Approved | Streptomyces garyphalus |
| References | ||||
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| Reference 1 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||