Molecule Details

General Information of the Molecule

Name

GTPase KRas (KRAS)

Synonyms

c-Ki-ras; c-K-ras; RASK2; Ki-Ras; KRAS2; K-Ras 2

Gene Name

KRAS

Gene ID

3845

Sequence

MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM

Click to Show/Hide

Function

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.

Click to Show/Hide

Uniprot ID

RASK_HUMAN

EC Number

EC: 3.6.5.2

Pfam

PF00071

KEGG ID

hsa3845

TTD ID

T48598

A List of Drug Combination(s) Able to Regulate This Molecule

Expression Regulation

Click to Show/Hide the Drug Combination Regulating This Molecule

Down-regulation

Click to Show/Hide

Drug Combination 1 Down-regulating the Expression of This Molecule

[1]

Detail(s)

Combination Info

click to show the detail info of this combination

Name

Luteolin NP Info

Gemcitabine Drug Info

Structure

References

Reference 1

Luteolin and Gemcitabine Protect Against Pancreatic Cancer in an Orthotopic Mouse Model. Pancreas. 2015 Jan;44(1):144-51.

Molecule Details

Cite NPCDR

Visitor Map

Correspondence

Prof. Feng ZHU (zhufeng@zju.edu.cn)

Prof. Xinbing SUI (hzzju@hznu.edu.cn)