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Molecule Details

General Information of the Molecule
Name
Bacterial Penicillin binding protein (Bact PBP)
Uniprot ID
NOUNIPROTAC
TTD ID
T34743
Natural Product(s) of This Target
1 Cefixime  NP Info  Approved Acremonium chrysogenum
Drug(s) of This Target
1 Ampicillin  Drug Info  Approved Bacterial infection
2 Ceftazidime  Drug Info  Approved Bacterial infection
3 Ceftriaxone  Drug Info  Approved Bacterial infection
4 Cefuroxime  Drug Info  Approved Acute bronchitis
5 Ciprofloxacin  Drug Info  Approved Bacterial infection
6 Clofarabine  Drug Info  Approved Myelodysplastic syndrome
7 Ertapenem  Drug Info  Approved Bacterial infection
8 Meropenem  Drug Info  Approved Bacterial infection
9 Oxacillin  Drug Info  Approved Bacterial infection
10 Piperacillin  Drug Info  Approved Bacterial infection
References
Reference 1 Genetics of chromosomally mediated intermediate resistance to ceftriaxone and cefixime in Neisseria gonorrhoeae. Antimicrob Agents Chemother. 2009 Sep;53(9):3744-51.
Reference 2 Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermediate, and -resistant pneumococci. Antimicrob Agents Chemother. 2002 May;46(5):1273-80.
Reference 3 New and emerging treatment of Staphylococcus aureus infections in the hospital setting. Clin Microbiol Infect. 2008 Apr;14 Suppl 3:32-41.
Reference 4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
Reference 5 Cefuroxime resistance in non-beta-lactamase Haemophilus influenzae is linked to mutations in ftsI. J Antimicrob Chemother. 2003 Mar;51(3):523-30.
Reference 6 Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
Reference 7 Clofarabine: past, present, and future. Leuk Lymphoma. 2007 Oct;48(10):1922-30.
Reference 8 Role of penicillin-binding protein 2 (PBP2) in the antibiotic susceptibility and cell wall cross-linking of Staphylococcus aureus: evidence for the cooperative functioning of PBP2, PBP4, and PBP2A. JBacteriol. 2005 Mar;187(5):1815-24.
Reference 9 Novel anion liposome-encapsulated antisense oligonucleotide restores susceptibility of methicillin-resistant Staphylococcus aureus and rescues mice... Antimicrob Agents Chemother. 2009 Jul;53(7):2871-8.
Reference 10 In vitro antienterococcal activity explains associations between exposures to antimicrobial agents and risk of colonization by multiresistant enter... J Infect Dis. 2004 Dec 15;190(12):2162-6.
Cite NPCDR
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Correspondence

X. N. Sun, Y. T. Zhang, Y. Zhou, X. C. Lian, L. L. Yan, T. Pan, T. Jin, H. Xie, Z. M. Liang, W. Q. Qiu, J. X. Wang, Z. R. Li, F. Zhu*, X. B. Sui*. NPCDR: natural product-based drug combination and its disease-specific molecular regulation. Nucleic Acids Research. 50(D1): 1324-1333 (2020). PMID: 34664659

Prof. Feng ZHU  (zhufeng@zju.edu.cn)

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China


Prof. Xinbing SUI  (hzzju@hznu.edu.cn)

School of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, China