Molecule Details
| General Information of the Molecule | ||||
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| Name |
Troponin C (TNNC1)
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| Synonyms |
Troponin C, slow skeletal and cardiac muscles; TNNC
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| Gene Name |
TNNC1
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| Gene ID | ||||
| Sequence |
MDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKVMRMLGQNPTPEELQEM
IDEVDEDGSGTVDFDEFLVMMVRCMKDDSKGKSEEELSDLFRMFDKNADGYIDLDELKIM LQATGETITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGVE Click to Show/Hide
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| Function |
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
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| Uniprot ID | ||||
| Pfam | ||||
| TTD ID | ||||
| Natural Product(s) of This Target | ||||
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| 1 | Levosimendan | NP Info | Approved | Homo sapiens |
| References | ||||
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| Reference 1 | Timing of levosimendan in cardiac surgery. Anadolu Kardiyol Derg. 2009 Jun;9(3):223-30. | |||