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Molecule Details

General Information of the Molecule
Name
Tubulin beta (TUBB)
Synonyms
Major cysteine proteinase; Cysteine proteinase cruzipain; Cruzaine; Congopain; Beta-tubulin
Uniprot ID
NOUNIPROTAC
TTD ID
T68536
Natural Product(s) of This Target
1 Paclitaxel  NP Info  Approved Taxus brevifolia
2 Vincristine  NP Info  Approved Catharanthus roseus
Drug(s) of This Target
1 Albendazole  Drug Info  Approved Parasitic worm infestation
References
Reference 1 Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77. Cancer Res. 2009 Sep 1;69(17):6906-14.
Reference 2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
Reference 3 Flubendazole interferes with a wide spectrum of cell homeostatic mechanisms in Echinococcus granulosus protoscoleces. Parasitol Int. 2009 Sep;58(3):270-7.
Cite NPCDR
Visitor Map
Correspondence

X. N. Sun, Y. T. Zhang, Y. Zhou, X. C. Lian, L. L. Yan, T. Pan, T. Jin, H. Xie, Z. M. Liang, W. Q. Qiu, J. X. Wang, Z. R. Li, F. Zhu*, X. B. Sui*. NPCDR: natural product-based drug combination and its disease-specific molecular regulation. Nucleic Acids Research. 50(D1): 1324-1333 (2020). PMID: 34664659

Prof. Feng ZHU  (zhufeng@zju.edu.cn)

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China


Prof. Xinbing SUI  (hzzju@hznu.edu.cn)

School of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, China