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Molecule Details

General Information of the Molecule
Name
Thymidylate kinase (DTYMK)
Synonyms
dTMP kinase
Gene Name
DTYMK
Gene ID
1841
Sequence
MAARRGALIVLEGVDRAGKSTQSRKLVEALCAAGHRAELLRFPERSTEIGKLLSSYLQKK
SDVEDHSVHLLFSANRWEQVPLIKEKLSQGVTLVVDRYAFSGVAFTGAKENFSLDWCKQP
DVGLPKPDLVLFLQLQLADAAKRGAFGHERYENGAFQERALRCFHQLMKDTTLNWKMVDA
SKSIEAVHEDIRVLSEDAIRTATEKPLGELWK
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Function
Catalyzes the conversion of dTMP to dTDP.
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Uniprot ID
KTHY_HUMAN
EC Number
EC: 2.7.4.9
Pfam
PF02223
KEGG ID
hsa1841
INTEDE ID
DME0415
Drug(s) of This Target
1 C1632  Drug Info  Investigative Lip/oral cavity/pharynx neoplasm
References
Reference 1 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Cite NPCDR
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Correspondence

X. N. Sun, Y. T. Zhang, Y. Zhou, X. C. Lian, L. L. Yan, T. Pan, T. Jin, H. Xie, Z. M. Liang, W. Q. Qiu, J. X. Wang, Z. R. Li, F. Zhu*, X. B. Sui*. NPCDR: natural product-based drug combination and its disease-specific molecular regulation. Nucleic Acids Research. 50(D1): 1324-1333 (2020). PMID: 34664659

Prof. Feng ZHU  (zhufeng@zju.edu.cn)

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China


Prof. Xinbing SUI  (hzzju@hznu.edu.cn)

School of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, China