Molecule Details
| General Information of the Molecule | ||||
|---|---|---|---|---|
| Name |
Gamma-Histone H2AX (H2AFX)
|
|||
| Synonyms |
Phosphorylation of H2AX; Histone H2AX; Histone H2A.x; H2a/x; H2AX
|
|||
| Gene Name |
H2AFX
|
|||
| Gene ID | ||||
| Sequence |
MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKK TSATVGPKAPSGGKKATQASQEY Click to Show/Hide
|
|||
| Function |
Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone
Click to Show/Hide
|
|||
| Uniprot ID | ||||
| KEGG ID | ||||
| TTD ID | ||||
| Natural Product(s) of This Target | ||||
|---|---|---|---|---|
| 1 | Micheliolide | NP Info | Michelia compressa | |
| 2 | Micheliolide | NP Info | Michelia compressa | |
| 3 | Tetrandrine | NP Info | Phase 1 | Stephania tetrandra |
| Drug(s) of This Target | ||||
|---|---|---|---|---|
| 1 | Temozolomide | Drug Info | Approved | Brain cancer |