Natural Product (NP) Details
| General Information of the NP (ID: NP0439) | |||||
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| Name |
Tetrandrine
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| Synonyms |
Tetrandrine, Millenia Hope; Tetrandrine, West Virginia University; Tranex-18
Click to Show/Hide
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| Species Origin | Stephania tetrandra ... | Click to Show/Hide | |||
| Stephania tetrandra | |||||
| Disease | Sarcoma [ICD-11: 2A60-2C35] | Phase 1 | [1] | ||
| Colorectal cancer [ICD-11: 2B91] | Discontinued in Phase 3 | [2] | |||
| Structure |
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Click to Download Mol2D MOL |
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| Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product | |||||
| Formula |
C38H42N2O6
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| PubChem CID | |||||
| Canonical SMILES |
CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC
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| InChI |
1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30-/m0/s1
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| InChIKey |
WVTKBKWTSCPRNU-KYJUHHDHSA-N
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| CAS Number |
CAS 518-34-3
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| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
| Cisplatin | Bladder cancer | Click to Show/Hide the Molecular Data of This Drug | ||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [3] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Molecule(s)
Regulation |
Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CDH1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CTNNB1 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | VEGFA | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | WNT5A | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | WNT5B | Molecule Info |
Pathway MAP
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| In-vitro Model | OVCAR-3 | CVCL_0465 | Ovarian serous adenocarcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Combination of Tetrandrine with cisplatin enhances cytotoxicity through growth suppression and apoptosis in ovarian cancer in vitro and in vivo. | |||||
| Target and Pathway | ||||
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| Target(s) | Calcium channel unspecific (CaC) | Molecule Info | [4] | |
