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Molecule Details

General Information of the Molecule
Name
Sodium/potassium ATPase (SPT ATPase)
Synonyms
Sodium/potassium-transporting ATPase; Na(+)/K(+) ATPase
Gene Name
ATP1A1; ATP1A2; ATP1A3; ATP1B1; ATP1B2; ATP1B3
Function
Maintain resting potential, affects transport, and regulates cellular volume. Function as a signal transducer/integrator to regulate the MAPK pathway, ROS, as well as intracellular calcium.
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Uniprot ID
AT1A1_HUMAN; AT1A2_HUMAN; AT1A3_HUMAN; AT1B1_HUMAN; AT1B2_HUMAN; AT1B3_HUMAN
TTD ID
T03917
Natural Product(s) of This Target
1 Sanguinarine  NP Info  Approved Bocconia frutescens
References
Reference 1 Medicinal plants in therapy. Bull World Health Organ. 1985;63(6):965-81.
Cite NPCDR
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Correspondence

X. N. Sun, Y. T. Zhang, Y. Zhou, X. C. Lian, L. L. Yan, T. Pan, T. Jin, H. Xie, Z. M. Liang, W. Q. Qiu, J. X. Wang, Z. R. Li, F. Zhu*, X. B. Sui*. NPCDR: natural product-based drug combination and its disease-specific molecular regulation. Nucleic Acids Research. 50(D1): 1324-1333 (2020). PMID: 34664659

Prof. Feng ZHU  (zhufeng@zju.edu.cn)

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China


Prof. Xinbing SUI  (hzzju@hznu.edu.cn)

School of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, China