Molecule Details

General Information of the Molecule

Name

Tyrosine phosphatase YVH1 (DUSP12)

Synonyms

Dual specificity tyrosine phosphatase YVH1; Dual specificity protein phosphatase 12

Gene Name

DUSP12

Gene ID

11266

Sequence

MLEAPGPSDGCELSNPSASRVSCAGQMLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVD
SEEPSFKAGPGVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVS
RSVAIITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQAMGYEVDTSSAIYK
QYRLQKVTEKYPELQNLPQELFAVDPTTVSQGLKDEVLYKCRKCRRSLFRSSSILDHREG
SGPIAFAHKRMTPSSMLTTGRQAQCTSYFIEPVQWMESALLGVMDGQLLCPKCSAKLGSF
NWYGEQCSCGRWITPAFQIHKNRVDEMKILPVLGSQTGKI

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Function

Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates.

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Uniprot ID

DUS12_HUMAN

EC Number

EC: 3.1.3.16 ; EC: 3.1.3.48

KEGG ID

hsa11266

A List of Drug Combination(s) Able to Regulate This Molecule

Expression Regulation

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Up-regulation

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Drug Combination 1 Up-regulating the Expression of This Molecule

[1]

Detail(s)

Combination Info

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Name

Resveratrol NP Info

Cisplatin Drug Info

Structure

References

Reference 1

Resveratrol Enhances Chemosensitivity in Mouse Melanoma Model Through Connexin 43 Upregulation. Environ Toxicol. 2015 Jul 8;30(8):877-86.

Molecule Details

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Correspondence

Prof. Feng ZHU (zhufeng@zju.edu.cn)

Prof. Xinbing SUI (hzzju@hznu.edu.cn)