Drug Combination Details
| General Information of the Combination (ID: C60407) | |||||
|---|---|---|---|---|---|
| Name | Resveratrol NP Info | + | Cisplatin Drug Info | ||
| Structure |
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| Disease |
Melanoma
[ICD-11: 2C30]
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Investigative | [1] | ||
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Lung cancer
[ICD-11: 2C25]
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Investigative | [2] | |||
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Breast cancer
[ICD-11: 2C60]
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Investigative | [3] | |||
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Hepatocellular carcinoma
[ICD-11: 2C12]
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Investigative | [4] | |||
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Prostate cancer
[ICD-11: 2C82]
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Investigative | [5] | |||
| Click to Show/Hide the Whole Disease Information of This Combination | |||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | MAP1LC3A | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | SQSTM1 | Molecule Info |
Pathway MAP
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| In-vitro Model | A-549 | CVCL_0023 | Lung adenocarcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Resveratrol combined with cisplatin synergistically induce apoptosis via modulating autophagic cell death in A549 cells. | |||||
| Experiment 2 Reporting the Effect of This Combination | [6] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| In-vitro Model | NCI-H838 | CVCL_1594 | Lung adenocarcinoma | Homo sapiens | ||
| NCI-H520 | CVCL_1566 | Lung squamous cell carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Resveratrol enhanced anticancer effects of cisplatin on non-small cell lung cancer cell lines by inducing mitochondrial dysfunction and cell apoptosis. | |||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [7] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BCL-xL | Molecule Info |
Pathway MAP
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| In-vitro Model | NCI-H446 | CVCL_1562 | Lung small cell carcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Resveratrol promotes the sensitivity of small-cell lung cancer H446 cells to cisplatin by regulating intrinsic apoptosis. | |||||
| Experiment 2 Reporting the Effect of This Combination | [5] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | DUSP12 | Molecule Info | ||
| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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| In-vitro Model | DU145 | CVCL_0105 | Prostate carcinoma | Homo sapiens | ||
| PC-3 | CVCL_0035 | Prostate carcinoma | Homo sapiens | |||
| LNCaP | CVCL_0395 | Prostate carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Resveratrol promotes apoptosis through the induction of dual specificity phosphatase 1 and sensitizes prostate cancer cells to cisplatin. | |||||
| Experiment 3 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | GJA1 | Molecule Info |
Pathway MAP
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| In-vitro Model | K1735 | CVCL_F828 | Mouse melanoma | Mus musculus | ||
| B16-F10 | CVCL_0159 | Mouse melanoma | Mus musculus | |||
| In-vivo Model | Animal models were constructed by inoculating subcutaneously with 106 B16F10 cells in male C57BL/6 mice. | |||||
| Experimental
Result(s) |
Resveratrol enhances chemosensitivity in mouse melanoma model through connexin 43 upregulation. | |||||
| Experiment 4 Reporting the Effect of This Combination | [3] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | RAD51 | Molecule Info |
Pathway MAP
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| In-vitro Model | MCF-7 | CVCL_0031 | Invasive breast carcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Resveratrol decreases Rad51 expression and sensitizes cisplatin resistant MCF-7 breast cancer cells. | |||||
| Experiment 5 Reporting the Effect of This Combination | [4] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | SLC1A5 | Molecule Info |
Pathway MAP
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| In-vitro Model | Hep-G2/C3A | CVCL_1098 | Hepatoblastoma | Homo sapiens | ||
| SMMC-7721 | CVCL_0534 | Hepatocellular carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Resveratrol enhances cisplatin-induced apoptosis in human hepatoma cells via glutamine metabolism inhibition. | |||||
