Molecule Details
| General Information of the Molecule | ||||
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| Name |
Thymic stromal lymphoprotein receptor (CRLF2)
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| Synonyms |
Thymic stromal lymphopoietin protein receptor; TSLP receptor; ILXR; Cytokine receptorlike factor 2; Cytokine receptorlike 2; CRLF2
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| Gene Name |
CRLF2
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| Gene ID | ||||
| Sequence |
MGRLVLLWGAAVFLLGGWMALGQGGAAEGVQIQIIYFNLETVQVTWNASKYSRTNLTFHY
RFNGDEAYDQCTNYLLQEGHTSGCLLDAEQRDDILYFSIRNGTHPVFTASRWMVYYLKPS SPKHVRFSWHQDAVTVTCSDLSYGDLLYEVQYRSPFDTEWQSKQENTCNVTIEGLDAEKC YSFWVRVKAMEDVYGPDTYPSDWSEVTCWQRGEIRDACAETPTPPKPKLSKFILISSLAI LLMVSLLLLSLWKLWRVKKFLIPSVPDPKSIFPGLFEIHQGNFQEWITDTQNVAHLHKMA GAEQESGPEEPLVVQLAKTEAESPRMLDPQTEEKEASGGSLQLPHQPLQGGDVVTIGGFT FVMNDRSYVAL Click to Show/Hide
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| Function |
Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system.
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| Uniprot ID | ||||
| KEGG ID | ||||
| TTD ID | ||||
| Drug(s) of This Target | ||||
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| 1 | BMS-231974 | Drug Info | Investigative | Breast cancer |
| References | ||||
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| Reference 1 | Thymic stromal lymphopoietin. Ann N Y Acad Sci. 2010 Jan;1183:13-24. | |||