Drug Details
| General Information of the Drug (ID: DR2625) | ||||
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| Name |
BMS-231974
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| Synonyms |
SCHEMBL6813836; SCHEMBL6813842; BMS-231974; 4-[(E)-2-[8-(3,3-dimethylbut-1-ynyl)-5,5,7-trimethyl-6H-naphthalen-2-yl]ethenyl]benzoic Acid
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| Molecular Type |
Small molecule
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| Disease | Breast cancer [ICD-11: 2C60] | Investigative | [1] | |
| Structure |
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| Formula |
C28H30O2
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| PubChem CID | ||||
| Canonical SMILES |
CC1=C(C2=C(C=CC(=C2)C=CC3=CC=C(C=C3)C(=O)O)C(C1)(C)C)C#CC(C)(C)C
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| InChI |
1S/C28H30O2/c1-19-18-28(5,6)25-14-11-21(17-24(25)23(19)15-16-27(2,3)4)8-7-20-9-12-22(13-10-20)26(29)30/h7-14,17H,18H2,1-6H3,(H,29,30)/b8-7+
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| InChIKey |
DQRQOOAPWNLJRO-BQYQJAHWSA-N
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| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| Paclitaxel | Taxus brevifolia | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [1] | |||||
| Detail(s) |
Combination Info
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| Molecule(s)
Regulation |
Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Up-regulation | Activity | JNK1 | Molecule Info |
Pathway MAP
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| In-vitro Model | MCF-7 | CVCL_0031 | Invasive breast carcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Alpha/beta selective retinoids dramatically lowered the effective dose of Taxol needed to induce cytotoxicity of a wide range of tumor cell lines. Examination of pathways common to Taxol and retinoid signaling revealed that this synergy was related in part to effects on Bcl-2 expression/phosphorylation as well as the activity of the c-Jun NH(2)-terminal kinase and activator protein-1. | |||||
| Target and Pathway | ||||
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| Target(s) | Thymic stromal lymphoprotein receptor (CRLF2) | Molecule Info | [2] | |
