| General Information of the Molecule |
| Name |
Dihydrodiol dehydrogenase I (AKR1C3)
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| Synonyms |
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Testosterone 17-beta-dehydrogenase 5; Prostaglandin F synthase; PGFS; KIAA0119; Indanol dehydrogenase; HSD17B5; HA1753; Dihydrodiol dehydrogenase 3; DDH1; DD3; DD-3; Chlordecone reductase homolog HAKRb; Aldo-keto reductase family 1 member C3; 3-alpha-hydroxysteroid dehydrogenase type 2; 3-alpha-HSD type II, brain; 3-alpha-HSD type 2; 17-beta-hydroxysteroid dehydrogenase type 5; 17-beta-HSD 5
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| Gene Name |
AKR1C3
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| Gene ID |
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| Sequence |
MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM
SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD
RNLHYFNSDSFASHPNYPYSDEY
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|
| Function |
Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
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| Uniprot ID |
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| EC Number |
EC: 1.1.1.-
; EC: 1.1.1.210
; EC: 1.1.1.53
; EC: 1.1.1.62
; EC: 1.1.1.357
; EC: 1.1.1.188
; EC: 1.1.1.239
; EC: 1.1.1.64
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| TC Number |
TC: 1.1.1.-; TC: 1.1.1.210; TC: 1.1.1.53; TC: 1.1.1.62; TC: 1.1.1.357; TC: 1.1.1.188; TC: 1.1.1.239; TC: 1.1.1.64
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| Pfam |
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| KEGG ID |
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| TTD ID |
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| INTEDE ID |
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