Drug Combination Details
| General Information of the Combination (ID: C01771) | |||||
|---|---|---|---|---|---|
| Name | Silibinin NP Info | + | Indole-3-carbinol Drug Info | ||
| Structure |
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+ |
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| Disease |
Lung cancer
[ICD-11: 2C25]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CCND1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | ERK1 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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| In-vitro Model | A-549 | CVCL_0023 | Lung adenocarcinoma | Homo sapiens | ||
| NCI-H460 | CVCL_0459 | Lung large cell carcinoma | Homo sapiens | |||
| In-vivo Model | Female A/J mice (5-6 weeks of age) received 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) (intraperitoneally, at a dose of 50 mg/Kg, twice a week, for a total of four doses) in 0.1 mL physiological saline solution. | |||||
| Experimental
Result(s) |
Exposure of the cells to a mixture of low concentrations of I3C (50 uM) plus silibinin (50 uM) for 72 h caused inhibition of cell growth and extracellular signal-regulated kinase (ERK) and Akt activation and induction of apoptosis, whereas the individual agents did not have any effect. | |||||
| β. Decreasing Adverse Drug Reaction by This Combination | ||||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CCND1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CDK2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CDK4 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | COX-2 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | NFKBIA | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | RB1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | STAT3 | Molecule Info |
Pathway MAP
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| In-vitro Model | Bronchial 1799 and 1198 cells | Healthy | Homo sapiens | |||
| Experimental
Result(s) |
Combinations of indole-3-carbinol and silibinin suppress inflammation-driven mouse lung tumorigenesis by modulating critical cell cycle regulators. | |||||
