Drug Combination Details
| General Information of the Combination (ID: C11292) | |||||
|---|---|---|---|---|---|
| Name | Elemene NP Info | + | Gefitinib Drug Info | ||
| Structure |
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| Disease |
Lung cancer
[ICD-11: 2C25]
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Phase 2 | [1] | ||
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Brain cancer
[ICD-11: 2A00]
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Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | EGFR | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | ERK1 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | PAEP | Molecule Info | |||
| In-vitro Model | U-251MG | CVCL_0021 | Astrocytoma | Homo sapiens | ||
| U-87MG ATCC | CVCL_0022 | Glioblastoma | Homo sapiens | |||
| Experimental
Result(s) |
Beta-Elemene enhances the efficacy of gefitinib on glioblastoma multiforme cells through the inhibition of the EGFR signaling pathway. | |||||
| Experiment 2 Reporting the Effect of This Combination | [3] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | CDH1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CDH2 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | HES1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | MYC | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | NOTCH1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | SHH | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | SNAI1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | SOX2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | TWIST1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | VIM | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | ZEB1 | Molecule Info |
Pathway MAP
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| In-vitro Model | A-549 | CVCL_0023 | Lung adenocarcinoma | Homo sapiens | ||
| NCI-H1299 | CVCL_0060 | Lung large cell carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Beta-Elemene synergizes with gefitinib to inhibit stem-like phenotypes and progression of lung cancer via down-regulating EZH2. | |||||
