Drug Combination Details
| General Information of the Combination (ID: C11337) | |||||
|---|---|---|---|---|---|
| Name | Honokiol NP Info | + | Celecoxib Drug Info | ||
| Structure |
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| Disease |
Breast cancer
[ICD-11: 2C60]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Decreasing Adverse Drug Reaction by This Combination | ||||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | FOXM1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | FOXP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | ITGAM | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MKI67 | Molecule Info | |||
| Down-regulation | Expression | NNT | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | PECAM1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | VEGFA | Molecule Info |
Pathway MAP
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| In-vitro Model | 4T1 | CVCL_0125 | Malignant neoplasms | Mus musculus | ||
| Experimental
Result(s) |
The combined treatment with PV-CXB and PV-HNK showed synergistic effect both in vitro and in vivo. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Tuning mPEG-PLA/vitamin E-TPGS-based mixed micelles for combined celecoxib/honokiol therapy for breast cancer. Eur J Pharm Sci. 2020 Apr 15;146:105277. | |||
