Drug Combination Details
| General Information of the Combination (ID: C12043) | |||||
|---|---|---|---|---|---|
| Name | Gambogic acid NP Info | + | Chloroquine Drug Info | ||
| Structure |
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| Disease |
Pancreatic cancer
[ICD-11: 2C10]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | BECN1 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP9 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | MAP1LC3A | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | SQSTM1 | Molecule Info |
Pathway MAP
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| In-vitro Model | PANC-1 | CVCL_0480 | Pancreatic ductal adenocarcinoma | Homo sapiens | ||
| BxPC-3 | CVCL_0186 | Pancreatic ductal adenocarcinoma | Homo sapiens | |||
| In-vivo Model | Xenograft tumor models were created by subcutaneously injecting 5*106 BxPC-3 cells into the right flank of the mice. | |||||
| Experimental
Result(s) |
Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species. | |||||
