Drug Combination Details
| General Information of the Combination (ID: C13131) | |||||
|---|---|---|---|---|---|
| Name | Curcumin NP Info | + | PP242 Drug Info | ||
| Structure |
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+ |
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| Disease |
Renal cell carcinoma
[ICD-11: 2C90]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | AKT1 | Molecule Info |
Pathway MAP
|
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| Down-regulation | Expression | RICTOR | Molecule Info |
Pathway MAP
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| Biological
Regulation |
Induction | Lysosomal membrane permeabilization | ||||
| In-vitro Model | Caki-1 | CVCL_0234 | Clear cell renal cell carcinoma | Homo sapiens | ||
| ACHN | CVCL_1067 | Papillary renal cell carcinoma | Homo sapiens | |||
| A-498 | CVCL_1056 | Renal cell carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Combined PP242 and curcumin treatment could induce autophagy-mediated cell death by reducing the expression of Rictor and Akt in renal carcinoma cells. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane permeabilization-mediated autophagy. Oncogene. 2018 Sep;37(38):5205-5220. | |||
