Drug Combination Details
| General Information of the Combination (ID: C13955) | |||||
|---|---|---|---|---|---|
| Name | Paeonol NP Info | + | Cisplatin Drug Info | ||
| Structure |
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+ |
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| Disease |
Esophageal cancer
[ICD-11: 2B70]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| In-vitro Model | SEG-1 | CVCL_8113 | Oesophageal cancer | Homo sapiens | ||
| Eca-109 | CVCL_6898 | Esophageal squamous cell carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Paeonol, in combination with cisplatin, had a significantly synergistic growth-inhibitory effect on oesophageal cell line, which may be related to apoptosis induction. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic effect of paeonol and cisplatin on oesophageal cancer cell lines. Dig Liver Dis. 2008 Jul;40(7):531-9. | |||
