Drug Combination Details

General Information of the Combination (ID: C15248)
Name Neferine   NP Info  + Imatinib   Drug Info 
Structure +
Disease
Acute lymphoblastic leukemia [ICD-11: 2B33]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [2]
                    Molecule(s)
                    Regulation		 Down-regulation Expression ABCB1  Molecule Info 
Pathway MAP
                    In-vitro Model K-562 CVCL_0004 Chronic myelogenous leukemia Homo sapiens
                    Experimental
                    Result(s)		 Nef is a candidate chemical that can increase STI571 chemosensitivity in STI571-resistant K562 cells by inhibition of P-gp expression and increasing intracellular STI571 accumulation.
                    Experiment 2 Reporting the Effect of This Combination [1]
                    Molecule(s)
                    Regulation		 Down-regulation Phosphorylation ERK1  Molecule Info 
Pathway MAP
Down-regulation Phosphorylation MCL1  Molecule Info 
Pathway MAP
                    In-vitro Model Bone marrow mononuclear cells derived from chronic myeloid leukemia patients Chronic myeloid leukemia Homo sapiens
                    Experimental
                    Result(s)		 These results suggest that neferine might be a potential imatinib sensitizer in CML treatment.
References
Reference 1 Neferine in the Lotus Plumule Potentiates the Antitumor Effect of Imatinib in Primary Chronic Myeloid Leukemia Cells In Vitro. J Food Sci. 2019 Apr;84(4):904-910.
Reference 2 Neferine increases STI571 chemosensitivity via inhibition of P-gp expression in STI571-resistant K562 cells. Leuk Lymphoma. 2011 Apr;52(4):694-700.
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