Drug Combination Details
| General Information of the Combination (ID: C15417) | |||||
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| Name | Jerusalem artichoke + Interferon alpha-2a | + | Ribavirin | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Jerusalem artichoke NP Info | Drug Info | |||
| Structure |
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| Name | Interferon alpha-2a NP Info | ||||
| Structure |
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| Disease |
Hepatic fibrosis/cirrhosis
[ICD-11: DB93]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | TGFB1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | TP53 | Molecule Info |
Pathway MAP
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| In-vivo Model | Male albino rats (150-200g) were used in this study. | |||||
| Experimental
Result(s) |
Addition of JAT as a supportive regimen to interferon and ribavirin effectively potentiates their anti-fibrotic effects. | |||||
