Natural Product (NP) Details
| General Information of the NP (ID: NP7887) | |||||
|---|---|---|---|---|---|
| Name |
Interferon alpha-2a
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| Species Origin | Homo sapiens ... | Click to Show/Hide | |||
| Homo sapiens | |||||
| Disease | Melanoma [ICD-11: 2C30] | Phase 3 | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
| Ribavirin | Hepatitis virus infection | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Molecule(s)
Regulation |
Down-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | TGFB1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | TP53 | Molecule Info |
Pathway MAP
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| In-vivo Model | Male albino rats (150-200g) were used in this study. | |||||
| Experimental
Result(s) |
Addition of JAT as a supportive regimen to interferon and ribavirin effectively potentiates their anti-fibrotic effects. | |||||
