Drug Combination Details
| General Information of the Combination (ID: C17243) | |||||
|---|---|---|---|---|---|
| Name | Apigenin NP Info | + | Gefitinib Drug Info | ||
| Structure |
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| Disease |
Lung cancer
[ICD-11: 2C25]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | BCL2L11 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CYB5R2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CYM | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | HIF-1A | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MYC | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | PRKAA1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | SLC2A1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | SLC2A3 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | SLC2A4 | Molecule Info |
Pathway MAP
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| Biological
Regulation |
Down-regulation | Autophagy flux | ||||
| Induction | Cell cycle arrest in G0/G1 phase | |||||
| In-vitro Model | NCI-H1975 | CVCL_1511 | Lung adenocarcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Apigenin combined with gefitinib blocks autophagy flux and induces apoptotic cell death through inhibition of HIF-1alpha, c-Myc, p-EGFR, and glucose metabolism in EGFR L858R+T790M-mutated H1975 Cells. | |||||
