Drug Combination Details
| General Information of the Combination (ID: C18218) | |||||
|---|---|---|---|---|---|
| Name | Triptolide NP Info | + | Tumor necrosis factor alpha Drug Info | ||
| Structure |
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+ |
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| Disease |
Hepatocellular carcinoma
[ICD-11: 2C12]
|
Investigative | [1] | ||
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Breast cancer
[ICD-11: 2C60]
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Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | COL11A2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | p105 | Molecule Info |
Pathway MAP
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| In-vitro Model | MDA-MB-231 | CVCL_0062 | Breast adenocarcinoma | Homo sapiens | ||
| MCF-7 | CVCL_0031 | Invasive breast carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Triptolide sensitized human breast cancer cells to TNF Alpha induced apoptosis. | |||||
| Experiment 2 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | PARP1 | Molecule Info |
Pathway MAP
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| In-vitro Model | HuCC-A1 | CVCL_M255 | Intrahepatic cholangiocarcinoma | Homo sapiens | ||
| KKU-100 | CVCL_3996 | Hilar cholangiocarcinoma | Homo sapiens | |||
| HubCCA-1 | Cholangiocarcinoma | Homo sapiens | ||||
| Experimental
Result(s) |
Apoptosis of human cholangiocarcinoma cell lines as induced by a combination of TNF-alpha and triptolide is mediated through caspase 3 activation. | |||||
